研究業績

フェアリー化合物

2023年

• "Role of hypoxanthine-guanine phosphoribosyltransferase in the salvage pathway of fairy chemicals in rice"
  Takemura, H., Choi, J-H., Fushimi, K., Narikawa, R., Kondo, M., Wu, J., Nelson, D. C., Suzuki, T., Ouchi, H., Inai, M., Hirai, H., and Kawagishi, H.
  Org. Biomol. Chem. 21, 22556-2561 (2023).

  • DOI: 10.1039/D3OB00026E
• "The role of xanthine dioxygenase in the biosynthetic pathway of 2-aza-8-oxohypoxanthine of Lepista sordida"
  Kotajima, M., Choi, J-H., Suzuki, T., Wu, J., Hirai, H., Nelson, D. C., Ouchi, H., Inai, M., Dohra, H., and Kawagishi, H.
  Bioscience, Biotechnology, and Biochemistry 87, 420-425 (2023).

  • DOI: 10.1093/bbb/zbad005

2022年

• "Utilization of corn steep liquor for the production of fairy chemicals by Lepista sordida Mycelia"
  Kobori, H., Wu, J., Takemura, H., Choi, J.-H., Tada, N., Kawagishi, H.
  J. Fungi 8, 12, 1269 (2022).

  • DOI: 10.3390/jof8121269
• "The fairy chemical imidazole-4-carboxamide inhibits the expression of Axl, PD-L1, and PD-L2 and improves response to cisplatin in cancer"
  Inoue, C., Yasuma, T., D'Alessandro-Gabazza, C. N., Toda, M., D'Alessandro, V. F., Inoue, R., Fujimoto, H., Kobori, H., Takeshita, A., NInoue, C., Yasuma, T., D'Alessandro-Gabazza, C. N., Toda, M., D'Alessandro, V. F., Inoue, R., Fujimoto, H., Kobori, H., Takeshita, A., Nishihama, K., Okano, Y., Wu, J., Kobayashi, T., Yano, Y., Kawagishi, H., and Gabazza, E. C. Gabazza, E. C.
  Cells 11, 374 (2022).

  • DOI: 10.3390/cells11030374
• "Potential of fairy chemicals as functional cosmetic ingredients: effect of 2-aza-8-oxohypoxanthine (AOH) on skin lightness"
  Aoshima, H., Ito, M., Ibuki, R., and Kawagishi, H.
  Int. J. Med. Mushr. 24, 9, 41-47 (2022).
• "1,2,3-Triazine formation mechanism of the fairy chemical 2-azahypoxanthine in the fairy ring-forming fungus Lepista sordida"
  *Ito, A., *Choi, J.-H., Waki, Y-M., Kotajima, M., Wu, J., Suzuki, T., Terashima, Y., Suzuki, H., Hirai, H., Nelson, D.C., Tsunematsu, Y., Watanabe, K., Asakawa, T., Ouchi, H., Inai, M., Dohra, H., Kawagishi, H.
  Org. Biomol. Chem. 20, 2636-2642 (2022).

2021年

• "An S-adenosylhomocysteine analogue of a fairy chemical, imidazole-4-carboxamide, as its metabolite in rice and yeast, and synthetic investigations of related compounds"
  Ouchi, H., Namiki, T., Iwamoto, K., Matsuzaki, N., Inai, M., Kotajima, M., Wu, J., Choi, J.-H., Kimura, Y., Hirai,H., Xie, X., Kawagishi, H., and Kan,T.
  J. Nat. Prod. 84, 453-458 (2021).

  • DOI: 10.2131/fts.8.123
• "Safety evaluation of 2-aza-8-oxohypoxanthine by in vitro skin sensitization and human tests"
  Aoshima, H., Matsumoto, T., Ibuki, R. and Kawagishi, H.
  Fundam. Toxicol. Sci. 8, 4, 123-133 (2021).

  • DOI: 10.3390/cosmetics8030083
• "Clinical evaluation of topical lotion containing 2-aza-8-oxohypoxanthine on skin barrier function against water loss"
  Aoshima, H., Ibuki, R., Ito, M., and Kawagishi, H.
  Cosmetics 8, 83 (2021).

2020年

• "Safety evaluation of 2-aza-8-oxohypoxanthine based on in vitro and human patch tests"
  Aoshima, H., Hyodo, S., Ibuki, R., Wu, J., Choi, J-H., Kawagishi, H.
  Fundam. Toxicol. Sci. 7, 5, 207-215 (2020).
• "Biosynthesis of the fairy chemicals, 2-azahypoxanthine and imidazole-4-carboxamide, in the fairy ring-forming fungus Lepista sordida"
  Ito, A., Choi, J-H., Takemura,H., Kotajima,M., Wu, J., Tokuyama, S., Hirai, H., Asakawa, Ouchi, H., Inai, M., Kan, T., and Kawagishi, H.
  J. Nat. Prod. 83, 2469-276 (2020).

2019年

• "Ribosides and ribotide of a fairy chemical, imidazole-4-carboxamide, as its metabolites in rice,"
  Choi, J-H., Matsuzaki,N., Wu, J., Kotajima, M., Hirai, H., Kondo, M., Asakawa, T., Inai, M., Ouchi, H., Kan, T., and Kawagishi, H.
  Org.Lett. 21, 7841-7845 (2019).
• "Genome sequence analysis of the fairy ring-forming fungus Lepista sordida and gene candidates for interaction with plants"
  Takano, T., Yamamoto, N., Suzuki, T., Dohra, H., Choi, J.-H., Terashima, Y., Yokoyama, K., Kawagishi, H., and Yano, K.
  Sci. Rep. 9, 5888 (2019).
• "A fairy chemical, imidazole-4-carboxamide, is produced on a novel purine metabolic pathway in rice"
  Takemura, H., Choi, J.-H., Matsuzaki, N., Taniguchi, Y., Wu, J., Hirai1, H., Motohashi1, R., Asakawa, T., Ikeuchi, K., Inai, M., Kan, T., and Kawagishi, H.
  Sci. Rep. 9, 9899 (2019).

2018年

• "Synthesis of double-13C-labeled imidazole derivatives"
  Ouchi, H., Asakawa, T., Ikeuchi, K., Inai, M., Choi, J.-H., Kawagishi, H., and Kan, T.
  Tetrahedron Lett. 59, 39, 3516-3518 (2018).
• "Discovery of plant growth stimulants by C－H arylation of 2_azahypoxanthine"
  Kitano, H., Choi, J.-H., Ueda, A., Ito, H., Hagihara,S., Kan, T., Kawagishi, H., and Itami, K.
  Org. Lett. 20, 18, 5684-5687 (2018).
• "N-Glucosides of fairy chemicals, 2-azahypoxanthine and 2-aza-8-oxohypoxanthine, in rice"
  Choi, J.-H., Wu, J., Sawada, A., Takemura, H., Yogosawa, K., Hirai, H., Kondo, M., Sugimoto, K., Asakawa, T., Inai, M., Kan, T., and Kawagishi, H.
  Org. Lett. 20, 312-314 (2018).
• "シバAgrostis stolonifera由来のコムラサキシメジ菌糸体に対する生育抑制物質"
  崔宰熏，呉静，伏見圭司，平井浩文，河岸洋和
  日本きのこ学会誌 25, 4, 141-144 (2018).