研究業績

キノコの機能性成分

2023年

• "“Fruiting Liquid” of Mushroom-Forming Fungi, A Novel Source of Bioactive Compounds – Fruiting-Body Inducer and HIF and Axl Inhibitors"
  Jing Wu, Kazuki Uchida, Aoto Yoshikawa, Masaru Hashimoto, Mitsuru Kondo, Kenichi Nihei, Mizuki Ishii, Jae-Hoon Choi, Yukihiro Miwa, Chiho Shoda, Deokho Lee, Ayaka Nakai, Toshihide Kurihara, Corina N. D’Alessandro-Gabazza, Masaaki Toda, Taro Yasuma, Esteban C. Gabazza, Hirofumi Hirai, and Hirokazu Kawagishi*
  J. Agric. Food Chem. (2023).

  • DOI: 10.1021/acs.jafc.3c03633
• "Novel cyclopropyl compounds, cyclopropylvirgines A to G, from the fruiting bodies of Amanita virgineoides"
  Wu, J., Kamiishi, Y., Shimozaki, K., Kondo, M., Hashimoto, M., Choi, J-H., D’Alessandro-Gabazza, C. N., Toda, M., Yasuma, T., Gabazza, E. C., Hirai, H., and Kawagishi H.
  Bull. Chem. Soc. Japan 12, 596-607 (2023).

  • DOI: 10.1246/bcsj.20230036
• "Bioactive compounds from the mushroom-forming fungus Chlorophyllum molybdites"
  Wu, J., Ohura, T., Ogura, R., Wang, J., Choi, J-H., Kobori, H., D’Alessandro-Gabazza, C. N., Toda, M., Yasuma, T., Gabazza, E. C., Takikawa, Y., H., Hirai, H., and Kawagishi H.
  Antibiotics 12, 596 (2023).

  • DOI: 10.3390/antibiotics12030596

2021年

• "A new lanostane triterpenoid from the mushroom Hypholoma fasciculare"
  Wang, J, Wu, J., Tsutsumi, K., Choi, J.-H., Hirai, H., Kobori, H.,Takikawa, Y., and Kawagishi, H.
  Biosci. Biotechnol. Biochem. 86, 7, 819-823 (2021).
• "An efficient heterologous Escherichia coli-based expression system for lectin production from Pleurocybella porrigens"
  Suzuki, T., Nakamura, L., Inayoshi, S., Tezuka, Y., Choi, J-H., Dohra, H., Sasanami, T. Hirai, H., and Kawagishi H.
  Biosci. Biotechnol. Biochem. 5, 630-633 (2021).

2020年

• "A fairy chemical suppresses retinal angiogenesis as a HIF inhibitor"
  Lee, D., Miwa, Y., Wu, J., Shoda, C., Jeong, H., Kawagishi, H., Tsubota, K., and Kurihara. T.
  Biomolecules 10, 1405 (2020).

  • DOI: 10.3390/biom10101405
• "蛍光色素ローダミンBを用いたシイタケ子実体生長過程における水分経路の可視化"
  窪田敏和, 鈴木智大, 金野尚武, 二宮尚
  日本きのこ学会誌 26, 164-168 (2020).
• "A GH family 28 endo-polygalacturonase from the brown-rot fungus Fomitopsis palustris: purification, gene cloning, enzymatic characterization and effects of oxalate"
  Tanaka Y., Suzuki T., Nakamura L., Nakamura M., Ebihara S., Kurokura T., Iigo M., Dohra H. Habu N., Konno N.
  Int. J. Biol. Macromol. 123, 108-116 (2020).
• "Starch-degrading enzymes from the brown-rot fungus Fomitopsis palustris"
  Tanaka Y., Konno N., Suzuki T., Habu N.
  Protein Expr. Purif. 170, 105609 (2020).
• "Non-destructive analysis of the moisture content in shiitake mushrooms (Lentinula edodes) using near-infrared imaging at 1450 nm"
  Shinoda K., Konno N., Suzuki T.
  Mycoscience 61, 235-239 (2020).
• "白色腐朽菌シイタケ由来エンド型 ポリガラクツロナーゼの精製と特性解析"
  田中裕基, 平間加那子, 鈴木智大, 羽生直人, 金野尚武
  日本きのこ学会誌 28, 123-128 (2020).
• "Axl and immune checkpoints inhibitors from the fruiting bodies of Pleurocybella porrigens"
  Ridwan, Y. A., Wu, J., Harada, E., D’Alessandro-Gabazza, C., Toda, M., Yasuma,T., Gabazza, E. C., Choi, J-H., Hirai, H., and Kawagishi, H.
  J. Antibiotic. 73, 733-736 (2020).
• "Plant growth regulators and axl and immune checkpoint inhibitors from the edible mushroom Leucopaxillus giganteus"
  Malya, I. Y., Wu, J., Harada, E., Toda, M., D’Alessandro-Gabazza, C. N., Yasuma,T., Gabazza, E. C., Choi, J-H., Hirai, H., and Kawagishia, H.
  Biosci. Biotechnol. Biochem. 80, 1332-1338 (2020).
• "Bitter compounds in two Tricholoma species, T. aestuans and T. virgatum"
  Oba, Y., Urai, M., Wu, J., Tomizawa, M., Kawagishi,H., and Hashimoto, K.
  J. Antibiotic. 73, 697-701 (2020).

  • DOI: 10.1038/s41429-020-0338-x
• "Effects of imidazole-4-carboxamide and 2-azahypoxanthine on the growth of Pinus densiflora seedlings and its ectomycorrhizal formation with Tricholoma matsutake"
  Nakano, S., Yamanaka, T., and Kawagishi, H.
  Mycoscience 61, 5, 259-263 (2020).
• "A biomimetic synthesis of chaxine and its related compounds"
  Niki, M., Hirata, Y., Nakazaki, A., Wu, J., Kawagishi, H., and Nishikawa, T.
  J. Org. Chem. 85, 7, 4848-4860 (2020).

  • DOI: 10.1021/acs.joc.9b03482
• "A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis"
  D’Alessandro-Gabazza, C., Kobayashi, T., Yasuma, T., Toda, M., Kim, H., Fujimoto, H., Hataji, O., Takeshita, A., Nishihama, K., Okano, Y., Okano, Y., Nishii, Y., Tomaru, A., Fujiwara, K., D'Alessandro, V. F., Abdel-Hamid, A., Ren, Y., Pereira, G., Wright, C., Hernandez, A., Fields, C., Yau, P., Wang, S., Mizoguchi, A., Fukumura, M., Ohtsuka, J., Nosaka, T., Kataoka, K., Kondoh, Y., Wu, J., Kawagishi, H., Yano, Y., Mackie, R., Cann, I., and Gabazza, E. C.
  Nature Commun. 11, 1539 (2020).

  • DOI: 10.1038/s41467-020-15344-3

2019年

• "Medicinal mushroom, Grifola gargal (Agaricomycetes), lowers triglyceride in animal models of obesity and diabetes and in adults with prediabetes"
  Harada, E., Morizono, T., Kanno, Saito, M., and Kawagishi, H.
  Int. J. Med. Mushr. 22, 1, 79-91 (2019).

  • DOI: 10.1615/IntJMedMushrooms.2019033285
• "Erinachromanes A and B and erinaphenol A from the culture broth of Hericium erinaceus"
  Wu, J., Uchida, K., Ridwan, A., Kondo, M., Choi, J.-H., Hirai, H., and Kawagishib, H.
  J. Agric. Food. Chem. 67, 3134-3139 (2019).
• "Array of bioactive metabolites in Italian Hericium erinaceus mycelium, primordium and sporophore"
  Corana, F., Cesaroni, V., Mannucci, B., Baiguera, R. M., Picco M. A., Savino, E., Ratto, D., Priori, C., Kawagishi, H., Girometta, C.E., and Rossi, P.
  Molecules 24, 3511 (2019).

  • DOI: 10.3390/molecules24193511
• "Efficient reconstitution of Basidiomycota diterpene erinacine gene cluster in Ascomycota host Aspergillus oryzae based on genomic DNA sequences"
  Liu, C., Minami, A., Ozaki, T., Wu, J., Kawagishi, H., Maruyama, J., and Oikawa, H.
  J. Am. Chem. Soc. 141, 15519-15523 (2019).

  • DOI: 10.1021/jacs.9b08935
• "Hericium erinaceus improves recognition memory and induces hippocampal and cerebellar neurogenesis in frail mice during aging"
  Ratto, D., Corana, F., Mannucci, B., Cecilia, E. Priori, Cobelli, F., Roda, E., Ferrari, B., Occhinegro, A., Iorio, C. D., Luca, F. D., Cesaroni, V., Girometta, C., Bottone, M. G., Savino, E., Kawagishi, H., and Rossi, P.
  Nutrients 11, 715 (2019).

  • DOI: 10.3390/nu11040715

2018年

• "Bioactive compounds from the edible mushroom Cortinarius caperatus"
  Ridwan, Y. A., Wu, J., Choi, J.-H., Hirai, H., and Kawagishi, H.
  Mycoscience 59, 2, 172-175 (2018).
• "The medicinal mushroom Grifola Gargal ameliorates Allergic bronchial asthma"
  Harada, E., D’Alessandro-Gabazza, C. N., Toda, M., Morizono, T., Totoki, T., Yasuma, T., Nishihama, K., Kobayashi, T. Sumiya, Kawagishi, H., and Gabazza. E. C.
  J. Med. Food 21, 2, 136-145 (2018).
• "A novel plant growth regulator from Pholiota lubrica"
  Ridwan, Y. A., Wu, J., Choi, J-H., Hirai, H., and Kawagishi, H.
  Tetrahedron Lett. 59, 26, 172-175 (2018).