研究業績

フェアリー化合物

2022年

• "Utilization of corn steep liquor for the production of fairy chemicals by Lepista sordida Mycelia"
  Kobori, H., Wu, J., Takemura, H., Choi, J.-H., Tada, N., Kawagishi, H.
  J. Fungi 8, 12, 1269 (2022).

  • DOI: 10.3390/jof8121269
• "The fairy chemical imidazole-4-carboxamide inhibits the expression of Axl, PD-L1, and PD-L2 and improves response to cisplatin in cancer"
  Inoue, C., Yasuma, T., D'Alessandro-Gabazza, C. N., Toda, M., D'Alessandro, V. F., Inoue, R., Fujimoto, H., Kobori, H., Takeshita, A., NInoue, C., Yasuma, T., D'Alessandro-Gabazza, C. N., Toda, M., D'Alessandro, V. F., Inoue, R., Fujimoto, H., Kobori, H., Takeshita, A., Nishihama, K., Okano, Y., Wu, J., Kobayashi, T., Yano, Y., Kawagishi, H., and Gabazza, E. C. Gabazza, E. C.
  Cells 11, 374 (2022).

  • DOI: 10.3390/cells11030374
• "Potential of fairy chemicals as functional cosmetic ingredients: effect of 2-aza-8-oxohypoxanthine (AOH) on skin lightness"
  Aoshima, H., Ito, M., Ibuki, R., and Kawagishi, H.
  Int. J. Med. Mushr. 24, 9, 41-47 (2022).
• "1,2,3-Triazine formation mechanism of the fairy chemical 2-azahypoxanthine in the fairy ring-forming fungus Lepista sordida"
  *Ito, A., *Choi, J.-H., Waki, Y-M., Kotajima, M., Wu, J., Suzuki, T., Terashima, Y., Suzuki, H., Hirai, H., Nelson, D.C., Tsunematsu, Y., Watanabe, K., Asakawa, T., Ouchi, H., Inai, M., Dohra, H., Kawagishi, H.
  Org. Biomol. Chem. 20, 2636-2642 (2022).

2021年

• "An S-adenosylhomocysteine analogue of a fairy chemical, imidazole-4-carboxamide, as its metabolite in rice and yeast, and synthetic investigations of related compounds"
  Ouchi, H., Namiki, T., Iwamoto, K., Matsuzaki, N., Inai, M., Kotajima, M., Wu, J., Choi, J.-H., Kimura, Y., Hirai,H., Xie, X., Kawagishi, H., and Kan,T.
  J. Nat. Prod. 84, 453-458 (2021).

  • DOI: 10.2131/fts.8.123
• "Safety evaluation of 2-aza-8-oxohypoxanthine by in vitro skin sensitization and human tests"
  Aoshima, H., Matsumoto, T., Ibuki, R. and Kawagishi, H.
  Fundam. Toxicol. Sci. 8, 4, 123-133 (2021).

  • DOI: 10.3390/cosmetics8030083
• "Clinical evaluation of topical lotion containing 2-aza-8-oxohypoxanthine on skin barrier function against water loss"
  Aoshima, H., Ibuki, R., Ito, M., and Kawagishi, H.
  Cosmetics 8, 83 (2021).

2020年

• "Safety evaluation of 2-aza-8-oxohypoxanthine based on in vitro and human patch tests"
  Aoshima, H., Hyodo, S., Ibuki, R., Wu, J., Choi, J-H., Kawagishi, H.
  Fundam. Toxicol. Sci. 7, 5, 207-215 (2020).
• "Biosynthesis of the fairy chemicals, 2-azahypoxanthine and imidazole-4-carboxamide, in the fairy ring-forming fungus Lepista sordida"
  Ito, A., Choi, J-H., Takemura,H., Kotajima,M., Wu, J., Tokuyama, S., Hirai, H., Asakawa, Ouchi, H., Inai, M., Kan, T., and Kawagishi, H.
  J. Nat. Prod. 83, 2469-276 (2020).

2019年

• "Ribosides and ribotide of a fairy chemical, imidazole-4-carboxamide, as its metabolites in rice,"
  Choi, J-H., Matsuzaki,N., Wu, J., Kotajima, M., Hirai, H., Kondo, M., Asakawa, T., Inai, M., Ouchi, H., Kan, T., and Kawagishi, H.
  Org.Lett. 21, 7841-7845 (2019).
• "Genome sequence analysis of the fairy ring-forming fungus Lepista sordida and gene candidates for interaction with plants"
  Takano, T., Yamamoto, N., Suzuki, T., Dohra, H., Choi, J.-H., Terashima, Y., Yokoyama, K., Kawagishi, H., and Yano, K.
  Sci. Rep. 9, 5888 (2019).
• "A fairy chemical, imidazole-4-carboxamide, is produced on a novel purine metabolic pathway in rice"
  Takemura, H., Choi, J.-H., Matsuzaki, N., Taniguchi, Y., Wu, J., Hirai1, H., Motohashi1, R., Asakawa, T., Ikeuchi, K., Inai, M., Kan, T., and Kawagishi, H.
  Sci. Rep. 9, 9899 (2019).

2018年

• "Synthesis of double-13C-labeled imidazole derivatives"
  Ouchi, H., Asakawa, T., Ikeuchi, K., Inai, M., Choi, J.-H., Kawagishi, H., and Kan, T.
  Tetrahedron Lett. 59, 39, 3516-3518 (2018).
• "Discovery of plant growth stimulants by C－H arylation of 2_azahypoxanthine"
  Kitano, H., Choi, J.-H., Ueda, A., Ito, H., Hagihara,S., Kan, T., Kawagishi, H., and Itami, K.
  Org. Lett. 20, 18, 5684-5687 (2018).
• "N-Glucosides of fairy chemicals, 2-azahypoxanthine and 2-aza-8-oxohypoxanthine, in rice"
  Choi, J.-H., Wu, J., Sawada, A., Takemura, H., Yogosawa, K., Hirai, H., Kondo, M., Sugimoto, K., Asakawa, T., Inai, M., Kan, T., and Kawagishi, H.
  Org. Lett. 20, 312-314 (2018).
• "シバAgrostis stolonifera由来のコムラサキシメジ菌糸体に対する生育抑制物質"
  崔宰熏，呉静，伏見圭司，平井浩文，河岸洋和
  日本きのこ学会誌 25, 4, 141-144 (2018).

キノコの機能性成分

2021年

• "An efficient heterologous Escherichia coli-based expression system for lectin production from Pleurocybella porrigens"
  Suzuki, T., Nakamura, L., Inayoshi, S., Tezuka, Y., Choi, J-H., Dohra, H., Sasanami, T. Hirai, H., and Kawagishi H.
  Biosci. Biotechnol. Biochem. 5, 630-633 (2021).
• "A new lanostane triterpenoid from the mushroom Hypholoma fasciculare"
  Wang, J, Wu, J., Tsutsumi, K., Choi, J.-H., Hirai, H., Kobori, H.,Takikawa, Y., and Kawagishi, H.
  Biosci. Biotechnol. Biochem. 86, 7, 819-823 (2021).

2020年

• "A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis"
  D’Alessandro-Gabazza, C., Kobayashi, T., Yasuma, T., Toda, M., Kim, H., Fujimoto, H., Hataji, O., Takeshita, A., Nishihama, K., Okano, Y., Okano, Y., Nishii, Y., Tomaru, A., Fujiwara, K., D'Alessandro, V. F., Abdel-Hamid, A., Ren, Y., Pereira, G., Wright, C., Hernandez, A., Fields, C., Yau, P., Wang, S., Mizoguchi, A., Fukumura, M., Ohtsuka, J., Nosaka, T., Kataoka, K., Kondoh, Y., Wu, J., Kawagishi, H., Yano, Y., Mackie, R., Cann, I., and Gabazza, E. C.
  Nature Commun. 11, 1539 (2020).

  • DOI: 10.1038/s41467-020-15344-3
• "A biomimetic synthesis of chaxine and its related compounds"
  Niki, M., Hirata, Y., Nakazaki, A., Wu, J., Kawagishi, H., and Nishikawa, T.
  J. Org. Chem. 85, 7, 4848-4860 (2020).

  • DOI: 10.1021/acs.joc.9b03482
• "Effects of imidazole-4-carboxamide and 2-azahypoxanthine on the growth of Pinus densiflora seedlings and its ectomycorrhizal formation with Tricholoma matsutake"
  Nakano, S., Yamanaka, T., and Kawagishi, H.
  Mycoscience 61, 5, 259-263 (2020).
• "Bitter compounds in two Tricholoma species, T. aestuans and T. virgatum"
  Oba, Y., Urai, M., Wu, J., Tomizawa, M., Kawagishi,H., and Hashimoto, K.
  J. Antibiotic. 73, 697-701 (2020).

  • DOI: 10.1038/s41429-020-0338-x
• "A fairy chemical suppresses retinal angiogenesis as a HIF inhibitor"
  Lee, D., Miwa, Y., Wu, J., Shoda, C., Jeong, H., Kawagishi, H., Tsubota, K., and Kurihara. T.
  Biomolecules 10, 1405 (2020).

  • DOI: 10.3390/biom10101405
• "Plant growth regulators and axl and immune checkpoint inhibitors from the edible mushroom Leucopaxillus giganteus"
  Malya, I. Y., Wu, J., Harada, E., Toda, M., D’Alessandro-Gabazza, C. N., Yasuma,T., Gabazza, E. C., Choi, J-H., Hirai, H., and Kawagishia, H.
  Biosci. Biotechnol. Biochem. 80, 1332-1338 (2020).
• "Axl and immune checkpoints inhibitors from the fruiting bodies of Pleurocybella porrigens"
  Ridwan, Y. A., Wu, J., Harada, E., D’Alessandro-Gabazza, C., Toda, M., Yasuma,T., Gabazza, E. C., Choi, J-H., Hirai, H., and Kawagishi, H.
  J. Antibiotic. 73, 733-736 (2020).
• "白色腐朽菌シイタケ由来エンド型 ポリガラクツロナーゼの精製と特性解析"
  田中裕基, 平間加那子, 鈴木智大, 羽生直人, 金野尚武
  日本きのこ学会誌 28, 123-128 (2020).
• "Non-destructive analysis of the moisture content in shiitake mushrooms (Lentinula edodes) using near-infrared imaging at 1450 nm"
  Shinoda K., Konno N., Suzuki T.
  Mycoscience 61, 235-239 (2020).
• "Starch-degrading enzymes from the brown-rot fungus Fomitopsis palustris"
  Tanaka Y., Konno N., Suzuki T., Habu N.
  Protein Expr. Purif. 170, 105609 (2020).
• "A GH family 28 endo-polygalacturonase from the brown-rot fungus Fomitopsis palustris: purification, gene cloning, enzymatic characterization and effects of oxalate"
  Tanaka Y., Suzuki T., Nakamura L., Nakamura M., Ebihara S., Kurokura T., Iigo M., Dohra H. Habu N., Konno N.
  Int. J. Biol. Macromol. 123, 108-116 (2020).
• "蛍光色素ローダミンBを用いたシイタケ子実体生長過程における水分経路の可視化"
  窪田敏和, 鈴木智大, 金野尚武, 二宮尚
  日本きのこ学会誌 26, 164-168 (2020).

2019年

• "Hericium erinaceus improves recognition memory and induces hippocampal and cerebellar neurogenesis in frail mice during aging"
  Ratto, D., Corana, F., Mannucci, B., Cecilia, E. Priori, Cobelli, F., Roda, E., Ferrari, B., Occhinegro, A., Iorio, C. D., Luca, F. D., Cesaroni, V., Girometta, C., Bottone, M. G., Savino, E., Kawagishi, H., and Rossi, P.
  Nutrients 11, 715 (2019).

  • DOI: 10.3390/nu11040715
• "Efficient reconstitution of Basidiomycota diterpene erinacine gene cluster in Ascomycota host Aspergillus oryzae based on genomic DNA sequences"
  Liu, C., Minami, A., Ozaki, T., Wu, J., Kawagishi, H., Maruyama, J., and Oikawa, H.
  J. Am. Chem. Soc. 141, 15519-15523 (2019).

  • DOI: 10.1021/jacs.9b08935
• "Array of bioactive metabolites in Italian Hericium erinaceus mycelium, primordium and sporophore"
  Corana, F., Cesaroni, V., Mannucci, B., Baiguera, R. M., Picco M. A., Savino, E., Ratto, D., Priori, C., Kawagishi, H., Girometta, C.E., and Rossi, P.
  Molecules 24, 3511 (2019).

  • DOI: 10.3390/molecules24193511
• "Erinachromanes A and B and erinaphenol A from the culture broth of Hericium erinaceus"
  Wu, J., Uchida, K., Ridwan, A., Kondo, M., Choi, J.-H., Hirai, H., and Kawagishib, H.
  J. Agric. Food. Chem. 67, 3134-3139 (2019).
• "Medicinal mushroom, Grifola gargal (Agaricomycetes), lowers triglyceride in animal models of obesity and diabetes and in adults with prediabetes"
  Harada, E., Morizono, T., Kanno, Saito, M., and Kawagishi, H.
  Int. J. Med. Mushr. 22, 1, 79-91 (2019).

  • DOI: 10.1615/IntJMedMushrooms.2019033285

2018年

• "A novel plant growth regulator from Pholiota lubrica"
  Ridwan, Y. A., Wu, J., Choi, J-H., Hirai, H., and Kawagishi, H.
  Tetrahedron Lett. 59, 26, 172-175 (2018).
• "The medicinal mushroom Grifola Gargal ameliorates Allergic bronchial asthma"
  Harada, E., D’Alessandro-Gabazza, C. N., Toda, M., Morizono, T., Totoki, T., Yasuma, T., Nishihama, K., Kobayashi, T. Sumiya, Kawagishi, H., and Gabazza. E. C.
  J. Med. Food 21, 2, 136-145 (2018).
• "Bioactive compounds from the edible mushroom Cortinarius caperatus"
  Ridwan, Y. A., Wu, J., Choi, J.-H., Hirai, H., and Kawagishi, H.
  Mycoscience 59, 2, 172-175 (2018).

キノコ毒

2021年

• "Quantification of ustalic acid, a chemotaxonomic marker, in Tricholoma ustale using liquid chromatography_mass spectrometry"
  Ito,T., Nagai, H., Aoki, W., Yamada, A., Kawagishi, H., Fukaya, M., and Konishi, H.
  J. Nat. Med. 75, 688-691 (2021).

  • DOI: 10.1007/s11418-021-01496-z
• "An Efficient Heterologous Escherichia coli-Based Expression System for Lectin Production from Pleurocybella porrigens"
  Suzuki T., Nakamura L., Inayoshi S., Tezuka Y., Ono A., Choi J-H, Dohra H., Sasanami T., Hirai H., Kawagishi H.
  Biosci. Biotechnol. Biochem. 85, 630-633 (2021).

冬虫夏草

2022年

• "CmLec4, a lectin from the fungus Cordyceps militaris, controls host infection and fruiting body formation."
  Ono A, Suzuki T, Takeshima Y, Kashiwa T, Motoyama T, Choi J-H, Sato C, Konno N, Miyakawa H, Ogata M, Hirai H, Dohra H, Osada H, Kawagishi H.
  Int. J. Biol. Macromol. 215, 303-311 (2022).

バイオリファイナリー

2022年

• "Ethanol fermentation by saprotrophic white-rot fungus Phanerochaete sordida YK-624 during wood decay as a system for short-term resistance to hypoxic conditions"
  Mori T., Masuda A., Kawagishi H., Hirai H.
  J. Biosci. Bioeng. 133, 1, 64-69 (2022).

2021年

• "Improvement of saccharide yield from wood by simultaneous enzymatic delignification and saccharification using a ligninolytic enzyme and cellulase"
  Mori T., Ikeda K., Kawagishi H., Hirai H.
  J. Biosci. Bioeng. 132, 3, 213-219 (2021).

2020年

• "木質バイオマスからのメタン発酵前処理に適した白色腐朽菌の選抜"
  日本きのこ学会誌 28, 2, 56-61 (2020).

2019年

• "Effects of glucose concentration on ethanol fermentation of white-rot fungus Phanerochaete sordida YK-624 under aerobic conditions"
  Mori T., Kondo O., Kawagishi H., Hirai H.
  Curr. Microbiol. 76, 3, 263-269 (2019).
• "Effect on growth, sugar consumption, and aerobic ethanol fermentation of homologous expression of the sugar transporter gene Pshxt1 in the white rot fungus Phanerochaete sordida YK-624"
  Mori T., Kondo O., Masuda A., Kawagishi H., Hirai H.
  J. Biosci. Bioeng. 128, 5, 537-543 (2019).

バイオレメディエーション

2021年

• "White-rot fungus Phanerochaete chrysosporium metabolizes chloropyridinyl-type neonicotinoid insecticides by an N-dealkylation reaction catalyzed by two cytochrome P450s"
  Mori T., Ohno H., Ichinose H., Kawagishi H., Hirai H.
  J. Hazard. Mater. 402, 123831 (2021).

2019年

• "Identification of the cytochrome P450 involved in the degradation of neonicotinoid insecticide acetamiprid in Phanerochaete chrysosporium"
  Wang J., Ohno H., Ide Y., Ichinose H., Mori T., Kawagishi H., Hirai H.
  J. Hazard. Mater. 371, 494-498 (2019).
• "Biotransformation and detoxification of the neonicotinoid insecticides nitenpyram and dinotefuran by Phanerochaete sordida YK-624"
  Wang J., Tanaka Y., Ohno H., Jia J., Mori T., Kawagishi H., Hirai H.
  Environ. Pollut. 252, A, 856-862 (2019).

2018年

• "Biodegradation of diuron in artificially contaminated water and seawater by wood colonized with the white-rot fungus Trametes versicolor"
  Mori T., Sudo S., Kawagishi H., Hirai H.
  J. Wood. Sci. 64, 690-696 (2018).

ゲノム研究

2022年

• "The complete mitochondrial genome of the whiterot fungus Phanerochaete sordida YK-624"
  T. Mori, H. Dohra, H. Kawagishi, H. Hirai
  Mitoch. DNA Part B: Res 7, 9, 1743-1745 (2022).

  • DOI: 10.1080/23802359.2022.2124830
• "The complete mitochondrial genome sequence of the fairy ring-forming fungus Lepista sordida"
  *Choi, J.-H., *Suzuki, T., Ono A., Kotajima, M., Tanaka, Y., Suzuki, T., Kawagishi, H., Dohra, H.
  Mitoch. DNA Part B: Res. 7, 4, 712-714 (2022).

2021年

• "Draft Genome Sequence of the White-Rot Fungus Phanerochaete sordida YK-624"
  T. Mori, H. Dohra, T. Suzuki, H. Kawagishi, H. Hirai
  Microbiol. Resour. Announc. 42, e0084221 (2021).
• "High-quality genome assembly of the soybean fungal pathogen Cercospora kikuchii"
  Kashiwa T, Suzuki T.
  Genes Genome. Genet. 27, jkab277 (2021).
• "Genetic sequence analysis and characterization of bioactive compounds in mushroom-forming fungi"
  Suzuki T.
  Biosci. Biotechnol. Biochem. 85, 8-12. (2021).

2019年

• "The complete mitochondrial genome sequence of the edible mushroom Stropharia rugosoannulata (Strophariaceae, Basidiomycota)"
  Suzuki, T., Ono, A., Choi, J.-H., Wu, J., Kawagishi, H., and Dohra, H.
  Mitoch. DNA Part B: Res. 4, 1, 507-572 (2019).
• "The complete mitochondrial genome sequence of the medicinal fungus Inonotus obliquus (Hymenochaetaceae, Basidiomycota)"
  Agnestisia R., Ono A., Nakamura L., Chino R., Nodera K., Aiso-Sanada H., Nezu I., Ishiguri F., Suzuki T., Yokota S.
  Mitochondrial DNA Part B 4, 3504-3506 (2019).
• "Draft genome sequence of Buttiauxella sp. A111 that converts 2-azahypoxanthine to 2-aza-8-oxohypoxanthine"
  Choi, J.-H., Moriuchi, R., Sukprasitchai, A., Tokuyama, S., Kawagishi, H., and Dohra, H.
  Microbiol. Res. Announc. 8, e00664-19 (2019).

木材腐朽

2021年

• "Transcriptomics analysis reveals the high biodegradation efficiency of white-rot fungus Phanerochaete sordida YK-624 on native lignin"
  Wang J.*, Suzuki T.*, Mori T.*, Yin R., Dohra H., Kawagishi H., Hirai H. (*Equal contribution)
  J. Biosci. Bioeng. 132, 3, 253-257 (2021).

2020年

• "Self-fusion and fusion cell isolation of transformants derived from white rot fungus Phanerochaete sordida YK-624 by simple visual method"
  Mori T., Kondo O., Sumiya T., Kawagishi H., Hirai H.
  J. Biosci. Bioeng. 129, 2, 146-149 (2020).

2018年

• "Functional characterization of the manganese transporter smf2 homologue gene, PsMnt, of Phanerochaete sordida YK-624 via homologous overexpression"
  Mori T., Nagai Y., Kawagishi H., Hirai H.
  FEMS Microbiol. Lett. 365, fny050 (2018).

総説・著書

2021年

• "きのこの生物活性と応用展開　第5章　フェアリー化合物の発見，基礎研究，そして実用化〜機能性化粧品原料としてのAOH製品開発〜"
  青島央江，河岸洋和
  河岸洋和（監修），シーエムシー出版, 352-359 (2021).
• "Chemical studies on bioactive compounds related to higher fungi"
  Kawagishi, H.
  Biosci. Biotechnol. Biochem. 85, 1, 1-7 (2021).

  • DOI: 10.1093/bbb/zbaa072

2020年

• "Plant growth regulators from mushrooms"
  Wu, J., Kawagishi, H
  J Antibiotic 73, 657-665 (2020).

  • DOI: 10.1038/s41429-020-0352-z
• "キノコ由来の生物活性2次代謝産物に関する化学的研究"
  呉静，河岸洋和
  化学と生物 58, 4, 231-239 (2020).

2019年

• "Chapter 18 – Chemistry of Fairy Rings. Green Science and Technology"
  Choi, J-H. and Kawagishi, H.
  (2019).
• "Are fairy chemicals a new family of plant hormones?"
  Kawagishi, H.
  Proc. Jpn. Acad., Ser. B 95, 1, 29-38 (2019).

  • DOI: 10.2183/pjab.95.003

2018年

• "植物成長を調節する化合物，「ケミカルバイオロジー化合物集　研究展開のヒント」"
  河岸洋和
  日本学術振興会ケミカルバイオロジー第189委員会（編），オーム社, 116-120 (2018).
• "Chapter 11 - Biologically Functional Compounds From Mushroom-Forming Fungus. Natural Products and Drug Discovery"
  Kawagishi, H.
  Elsevier, eds: Subhash C. Mandal Vivekananda Mandal Tetsuya Konishi, 309-326 (2018).
• "“フェアリーリング”の謎を化学で解く，「天然有機分子の構築」（化学の要点シリーズ26）"
  河岸洋和
  日本化学会（編），共立出版, 94-97 (2018).
• "Fairy chemicals – a candidate for a new family of plant hormones and possibility of practical use in agriculture –"
  Kawagishi, H.
  Biosci. Biotechnol. Biochem. 82, 5, 752-758 (2018).

  • DOI: 10.1080/09168451.2018.1445523
• "きのこが産生する生体機能性物質に関する研究"
  河岸洋和
  日本きのこ学会誌 25, 4, 122-128 (2018).